The Hopkinton Fire Department responded to a house fire on Pine Island Road at 12:45 a.m. Saturday morning in sub-zero temperatures.

According to the department’s Twitter page, “First-arriving companies found heavy fire from a two-story wood frame.”

Mutual aid came from Ashland, Milford, Westborough, Southborough, Hopedale and Upton. HFD reported no injuries to the occupants or firefighters.