Hopkinton Wellness and Hopkinton Card & Gift have existed in some form for almost seven decades in the center of town. That’s about to change.

Husband-and-wife owners Dennis Katz and Terry Anthony are planning to close the businesses at 52 Main Street — on the corner of Route 135 and Route 85 — and the building is available for rent or lease. The property includes the home at 6 Cedar Street, an adjoining parcel that the company bought about 20 years ago as a potential expansion or parking, Katz said.

“It’s time,” Katz said. “I still have my health, I still have a lot of good energy. Now I have an opportunity to try and take a little bit better care of myself than I’ve had an opportunity to do over the last 15 or so years, running this place. It’s time. I feel good about it. I feel very good about it.”

A rental sign was placed outside the store Friday, and Katz said there already has been a lot of interest — “a big rush in the beginning, that will dwindle out, we’ll see where the chips fall.”

Update, June 3, 11 a.m.: Anthony shared that there is no set closing date planned for now. While the businesses are “winding down,” they will remain open indefinitely.

Katz said the building — which initially was much smaller than the current facility — originally was divided into three small businesses. Katz’s parents opened the pharmacy in 1954 in one section that they rented, with a five-and-dime and a barber shop in the others.

Katz grew up in town — in a three-family home located where the now-closed Santander Bank building is located at 66 Main Street. He took over as president of Hopkinton Drug from his father in 1980.

Through the years, the building was expanded and, while Hopkinton Drug was a constant, various businesses came and went in the other part of the building, including restaurants and a store that sold video cassette players.

Eventually, Hopkinton Card & Gift took over the entire upstairs section. The Hopkinton Drug pharmacy business, meanwhile, was sold last year to Texas-based PD Labs, although Katz started a new business that focuses on formulary research — and he plans to continue that work. He also hopes to do some traveling.

“It’s been a pleasure serving and being a member of the community,” Katz said. “I enjoyed doing my work, and I enjoyed trying to be helpful. That was always part of my family’s scheme, and hopefully that was achieved.”